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Computational Genomics

Hematopoietic stem cells (HSCs) and their maintenance/differentiation are regulated by complex mechanisms including epigenetic changes and transcription factor regulatory networks. A snapshot of how these processes are working can be captured using next generation sequencing (NGS).

These techniques are presently being implemented at the level of the single cell, allowing us to measure the degree of heterogeneity present within a population of cells. This raises a number of computational challenges such as how to find sub-populations of cells (that may be functionally different) in amongst noisey data, and this is the focus of our lab.

RNA stem cells
The process of gene regulation can be studied at various stages from chromatin structure to RNA expression using next generation sequencing based methods. Image source: www.encodeproject.org
Page Manager:

Shamit Soneji

Shamit Soneji

PhD, Assistant Professor

Phone: +46 46 222 08 72
Email: shamit [dot] soneji [at] med [dot] lu [dot] se

LUCRIS PROFILE

Research

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Current major grants

Molecular Hematology
Department of Laboratory Medicine, Faculty of Medicine
Lund University
Box 117
SE-221 00 LUND
SWEDEN

E-mail & phone: info [at] med [dot] lu [dot] se  +46 (0)46 222 0000