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Jenny Hansson Group

Proteomic Hematology

Background


Proteins are the machinery of the cell, responsible for executing the functions essential for cells to operate, survive, differentiate and divide. Increasing evidence emphasises that a substantial variance of protein expression is conveyed at the levels of protein synthesis and degradation, and that post-transcriptional control of gene expression plays a critical role in multiple aspects of cell biology, including coordination of cellular processes and rapid alteration of cellular phenotype. Importantly, the proteomic make-up of blood stem cells and progenitors can regulate their cell fate and susceptibility to initiation as well as progression of leukemia.

Our research


The broad interest of our group lies in understanding the molecular differences between fetal and adult hematopoiesis. By using in-depth mass spectrometry-based quantitative proteomics to monitor protein levels in a comprehensive and quantitative manner, our research aims to:

  • define the fetal- and adult-specific proteomic programs that regulate normal and malignant hematopoiesis.
  • use this knowledge to perturb proteins of ontogeny-specific leukemic features.

Our work will advance the understanding of ontogenic influence on hematopoiesis and create a basis for the identification of novel age-tailored therapeutic approaches for treatment in young and old leukemic patients.

Selected publications

  1. Jassinskaja M., Johansson E., Kristiansen T.A., Åkerstrand H., Sjöholm K., Hauri S., Malmström J., Yuan J., Hansson J.; Comprehensive Proteomic Characterization of Ontogenic Changes in Hematopoietic Stem and Progenitor Cells. Cell Reports. 2017; 21(11):3285-3297.
     
  2. Li H., Lim H.C., Zacharaki D., Xian X., Kenswil KJ., Bräunig S., Raaijmakers M.H., Woods N.B., Hansson J., Scheding S., Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells. Haematologica. 2019 doi: 10.3324/haematol.2019.216648.
     
  3. Raffel S., Falcone M., Kneisel N., Hansson J., Wang W., Lutz C., Bullinger L., Poschet G., Nonnenmacher Y., Barnert A., Bahr C., Zeisberger P., Przybylla A., Sohn M., Tönjes M., Erez A., Adler L., Jensen P., Scholl C., Fröhling S., Cocciardi S., Wuchter P., Thiede C., Flörcken A., Westermann J., Ehninger G., Lichter P., Hiller K., Hell R., Herrmann C., Ho A.D., Krijgsveld J., Radlwimmer B., Trumpp A.; BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Nature. 2017; 551(7680):384-388.
     
  4. Cabezas-Wallscheid N., Klimmeck D., Hansson J., Lipka D.B., Reyes A., Wang Q., Weichenhan D., Lier A., von Paleske L., Renders S., Wuensche P., Zeisberger P., Brocks D., Gu L., Herrmann C., Haas S., Essers M.A.G., Brors B., Eils R., Huber W., Milsom M.D., Plass C., Krijgsveld J., Trumpp A.; Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome and DNA methylome analysis; Cell Stem Cell. 2014;15(4):507-22.
     
  5. Haas S., Hansson J., Klimmeck D., Loeffler D., Velten L., Uckelmann H., Wurzer S., Prendergast Á.M., Schnell A., Hexel K., Santarella-Mellwig R., Blaszkiewicz S., Kuck A., Geiger H., Milsom M.D., Steinmetz L.M., Schroeder T., Trumpp A., Krijgsveld J., Essers M.A.; Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell. 2015;17(4):422-34.
Page Manager:

Jenny Hansson

Janny Hansson

Associate Senior Lecturer

Phone: +46 (0)46 222 05 08
Email: jenny [dot] hansson [at] med [dot] lu [dot] se

Lund University Research Portal

Group members

Maria Jassinskaja
PhD student
maria [dot] jassinskaja [at] med [dot] lu [dot] se

Kristyna Pimkova
Assistant Researcher
kristyna [dot] pimkova [at] med [dot] lu [dot] se

Sudip Ghosh
Postdoc
sudip [dot] ghosh [at] med [dot] lu [dot] se

Visiting address

Division of Molecular Hematology
Lund Stem Cell Center, Lund University
Klinikgatan 26
SE-221 84 Lund
SWEDEN

Room: BMC, B1218b

Molecular Hematology
Department of Laboratory Medicine, Faculty of Medicine
Lund University
Box 117
SE-221 00 LUND
SWEDEN

E-mail & phone: info [at] med [dot] lu [dot] se  +46 (0)46 222 0000