David Bryder Group
Hematopoietic (blood) stem cells (HSCs) are rare but highly potent cells located in the bone marrow that have an ability to produce all types of blood cells (multilineage capacity) and to give rise to new stem cells (self-renewal). These properties enable an individual to maintain blood cell production over a lifetime.
Our research focus on how HSCs and their immediate offspring are regulated. Although HSCs are associated with a fairly clear functional definition regarding their potentials, all HSCs do not behave the same. One example is during fetal development, where HSCs can give rise to certain specialized blood cells that are not regenerated in adults.
Our goal is to understand what controls HSCs and the fate of other immature blood cells in normal and disease-contexts (leukemia). Enhanced knowledge in this area can be used both preventively and therapeutically, by being able to expand the use of HSC transplantation as a therapy, but also in the development of HSC-based therapies that do not involve direct transplantat ion.
We use advanced cell sorting and a range of cellular and newer molecular biology techniques, including massive parallel-sequencing and Cas9/Crispr-based approaches, many which are applied at the level of single cells. We apply and develop novel transgenic mouse models.
- Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging. Säwen P, Eldeeb M, Erlandsson E, Kristiansen TA, Laterza C, Kokaia Z, Karlsson G, Yuan J, Soneji S, Mandal PK, Rossi DJ, Bryder D. Elife. 2018 Dec 18;7. pii: e41258. doi: 10.7554/eLife.41258. PMID:30561324
- Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor. Wahlestedt M, Ladopoulos V, Hidalgo I, Sanchez Castillo M, Hannah R, Säwén P, Wan H, Dudenhšffer-Pfeifer M, Magnusson M, Norddahl GL, Gšttgens B, Bryder D. Cell Rep. 2017 Nov 21;21(8):2251-2263. doi: 10.1016/j.celrep.2017.10.112. PMID:29166614
- Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate. Wahlestedt M, Erlandsson E, Kristiansen T, Lu R, Brakebusch C, Weissman IL, Yuan J, Martin-Gonzalez J, Bryder D. Nat Commun. 2017 Feb 22;8:14533. doi: 10.1038/ncomms14533. PMID:28224997
- Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis. Säwén P, Lang S, Mandal P, Rossi DJ, Soneji S, Bryder D. Cell Rep. 2016 Mar 29;14(12):2809-18. doi: 10.1016/j.celrep.2016.02.073. Epub 2016 Mar 17. PMID:26997272
- Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated transformation. Ugale A, Norddahl GL, Wahlestedt M, Säwén P, Jaako P, Pronk CJ, Soneji S, Cammenga J, Bryder D. Cell Rep. 2014 Nov 20;9(4):1246-55. doi: 10.1016/j.celrep.2014.10.036. Epub 2014 Nov 13. PMID:25456127
Phone: +46 (0)46 222 39 51
Mobile: +46 (0)70 642 39 51
Email: david [dot] bryder [at] med [dot] lu [dot] se
haixia [dot] wan [at] med [dot] lu [dot] se
mohamed [dot] eldeeb [at] med [dot] lu [dot] se
ouyang [dot] yuan [at] med [dot] lu [dot] se
anna [dot] konturek-ciesla [at] med [dot] lu [dot] se
Division of Molecular Hematology
Lund Stem Cell Center, Lund University
SE-221 84 Lund
Room: BMC, B1235b