Ewa Sitnicka Quinn Group
The immune system is composed of several types of myeloid and lymphoid white blood cells collectively protecting the body from different pathogens and from the growth of cancer cells.
All cells in the immune system are produced from blood stem cells. This process involves several differentiation stages that are driven and controlled by a network of regulatory pathways.
The lymphoid cells include: T (thymus-dependent), B (bone marrow-derived) and NK (natural killer) cells. NK cells play critical role in protection against infectious pathogens and in preventing cancer, and activate the function of the other cells of the immune system.
NK cell-deficiencies correlate with higher cancer incidence and increased infections. NK cell-based therapies have been used in the clinic to treat cancer patients. In contrast to T and B cells, the origin of NK cells is not well defined.
The overall aim of our work is to establish a NK cell developmental map and identify critical NK lineage regulators. We are also studying how cancer cells escape NK cell surveillance and how NK cell development and function is altered in leukemia.
This new knowledge will help to better understand blood diseases (immune-deficiencies and leukemia), and to improve therapy against cancer and infections.
- Chaves P, Zriwil A, Wittmann L, Boukarabila H, Peitzsch C, Jacobsen SEW and Sitnicka E. Loss of canonical Notch signaling affects multiple steps in NK cell development in mice. Journal of Immunology, 2018; 201:3307-19
* This article was selected by the Editor-in-Chief as one of the top 10% articles published in The Journal and is featured in the Section “In This Issue”.
- Renoux VM, Zriwil A, Peitzsch C, Michaëlsson J, Friberg D, Soneji S and Sitnicka E. Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues. Immunity, 2015; 43:394-407
- Cichocki F, Sitnicka E, Bryceson YT. NK cell development and function – plasticity and redundancy unleashed. Seminars in Immunology, 2014, 26:114-26
- Tang Y, Peitzsch C, Charoudeh HN, Cheng M, Chaves P, Jacobsen SE and Sitnicka E. Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo. Blood, 2012; 120: 63-75
- Nozad Charoudeh H, Tang Y, Cheng M, Cilio CM, Jacobsen SE and Sitnicka E. Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells. Blood, 2010; 116:183-192
Ewa Sitnicka Quinn
Phone: +46 (0)46 222 46 76
Mobile: +46 (0)73 047 72 64
Email: ewa [dot] sitnicka_quinn [at] med [dot] lu [dot] se
PhD, Postdoctoral fellow
gladys [dot] telliam [at] med [dot] lu [dot] se
Dang Nghiem Vo
PhD, Postdoctoral fellow
dang [dot] nghiem_vo [at] med [dot] lu [dot] se
PhD, Research Engineer
olga [dot] kotova [at] med [dot] lu [dot] se
Division of Molecular Hematology
Lund Stem Cell Center, Lund University
SE-221 84 Lund
Room: BMC, B1216b